ANTIBIOTICS CHEAT SHEET :)
* Sulfonamides compete for albumin with:
- Bilirrubin: given in 2°,3°T, high risk or indirect hyperBb and kernicterus in premies
- Warfarin: increases toxicity: bleeding
* Beta-lactamase (penicinillase) Suceptible:
- Natural Penicillins (G, V, F, K)
- Aminopenicillins (Amoxicillin, Ampicillin)
- Antipseudomonal Penicillins (Ticarcillin, Piperacillin)
* Beta-lactamase (penicinillase) Resistant:
- Oxacillin, Nafcillin, Dicloxacillin
- 3°G, 4°G Cephalosporins
- Beta-lactamase inhibitors
* Penicillins enhanced with:
- Clavulanic acid & Sulbactam (both are suicide inhibitors, they inhibit beta-lactamase)
- Aminoglycosides (against enterococcus and psedomonas)
* Aminoglycosides enhanced with Aztreonam
* Penicillins: renal clearance EXCEPT Oxacillin & Nafcillin (bile)
* Cephalosporines: renal clearance EXCEPT Cefoperazone & Cefrtriaxone (bile)
* Both inhibited by Probenecid during tubular secretion.
* 2°G Cephalosporines: none cross BBB except Cefuroxime
* 3°G Cephalosporines: all cross BBB except Cefoperazone bc is highly highly lipid soluble, so is protein bound in plasma, therefore it doesn’t cross BBB.
* Cephalosporines are ”LAME" bc they do not cover this organisms
- L isteria monocytogenes
- A typicals (Mycoplasma, Chlamydia)
- M RSA (except Ceftaroline, 5°G)
- E nterococci
* Disulfiram-like effect: Cefotetan & Cefoperazone (mnemonic)
* Cefoperanzone: all the exceptions!!!
- All 3°G cephalosporins cross the BBB except Cefoperazone.
- All cephalosporins are renal cleared, except Cefoperazone.
- Disulfiram-like effect
* Against Pseudomonas:
- 3°G Cef taz idime (taz taz taz taz)
- 4°G Cefepime, Cefpirome (not available in the USA)
- Antipseudomonal penicillins
- Aminoglycosides (synergy with beta-lactams)
* Covers MRSA: Ceftaroline (rhymes w/ Caroline, Caroline the 5°G Ceph), Vancomycin, Daptomycin, Linezolid, Tigecycline.
* Covers VRSA: Linezolid, Danupristin/Quinupristin
* Aminoglycosides: decrease release of ACh in synapse and act as a Neuromuscular blocker, this is why it enhances effects of muscle relaxants.
* DEMECLOCYCLINE: tetracycline that’s not used as an AB, it is used as tx of SIADH to cause Nephrogenic Diabetes Insipidus (inhibits the V2 receptor in collecting ducts)
* Phototoxicity: Q ue S T ion?
- Q uinolones
- T etracyclines
* p450 inhibitors: Cloramphenicol, Macrolides (except Azithromycin), Sulfonamides
* Macrolides SE: Motilin stimulation, QT prolongation, reversible deafness, eosinophilia, cholestatic hepatitis
* Bactericidal: beta-lactams (penicillins, cephalosporins, monobactams, carbapenems), aminoglycosides, fluorquinolones, metronidazole.
* Baceriostatic: tetracyclins, streptogramins, chloramphenicol, lincosamides, oxazolidonones, macrolides, sulfonamides, DHFR inhibitors.
* Pseudomembranous colitis: Ampicillin, Amoxicillin, Clindamycin, Lincomycin.
* QT prolongation: macrolides, sometimes fluoroquinolones
Motivate the people you love, even the people you dislike. Motivate them to be great, don’t ever talk negatively about their dreams. Great people lead to a great world, an overall better life. Surround yourself with greatness, and live your dreams while assisting others in doing the same.Moroney (via thatlitsite)
Julie Schumacher’s first novel, The Body Is Water, was a finalist for the PEN/Hemingway Award. She’s a faculty member in the Creative Writing Program at the University of Minnesota, a job that presumably gave her some raw material for her new academic farce, Dear Committee Members. Book critic Maureen Corrigan has a review:
For all you teachers out there contemplating the August calendar with dismay, watching, powerless, as the days of summer vacation dwindle down to a precious few, I have some consolation to offer: a hilarious academic novel that’ll send you laughing (albeit ruefully) back into the trenches of the classroom. Julie Schumacher’s novel is called Dear Committee Members and one of the reasons why it’s such a mordant minor masterpiece is the fact that Schumacher had the brainstorm to structure it as an epistolary novel. This book of letters is composed of a year’s worth of recommendations that our anti-hero—a weary professor of creative writing and literature—is called upon to write for junior colleagues, lackluster students, and even former lovers. The gem of a law school recommendation letter our beleaguered professor writes for a cutthroat undergrad who he’s known for all of “eleven minutes,” is alone worth the price of Schumacher’s book.
Photo Jane Inman Stormer via Flickr